Letter | Published:

Penetration of Benzpyrene through the Intact Skin of New-Born Mice

Nature volume 166, pages 188189 (29 July 1950) | Download Citation

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Abstract

WHEN the skin of the mouse is painted with a benzene or an acetone solution of a carcinogenic hydrocarbon, it is found afterwards that a part of the carcinogen remains in the keratinized layer of the epidermis, while some of the carcinogen (fluorescent material) immediately enters the pilo-sebaceous apparatus and is found dissolved in the lipid droplets within the gland cells. Several authors have suggested that the pilo-sebaceous apparatus plays an important part in the genesis of skin cancer by providing channels through which the carcinogen may penetrate the epidermis1. It was thought that a study of carcinogenic action on new-born mice2,3,4 would throw light on this problem, for it has been observed that newborn mice (2–10 hr. after birth) are refractory to a single application of methylcholanthrene. The absence of sebaceous glands, the lack of a way of entering via the hair follicles and also the thicker epidermis of new-born mice, confirmed by histological examination, would explain ineffectiveness of methylcholanthrene for tumour formation. The literature does not seem to contain any convincing evidence that the carcinogen is absorbed by the epidermal epidermis without mediation of the follicular pathways.

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Author information

Affiliations

  1. Department of Radiology, Second Medical Clinic, University of Helsinki.

    • KAI SETÄLÄ
  2. Institute of Physical Chemistry, Swedish University of Åbo, “Åbo Akademi”, Finland. Feb. 1.

    • PER EKWALL

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DOI

https://doi.org/10.1038/166188b0

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