Abstract
DICUMAROL1 is widely used clinically for the treatment of thrombosis. Since very little is known about the mechanism whereby dicumarol lowers the prothrombin-level in blood2, it was thought that experiments with dicumarol labelled with carbon-14 might be of value. The dicumarol was prepared by adding an aqueous solution of formaldehyde containing carbon-14, obtained from the Oak Ridge National Laboratory, to a saturated aqueous solution of 4-hydroxycoumarin3. The 3,3′-methylene-C14-bis(4-hydroxycoumarin) so obtained had a specific activity of 6 × 104 counts per minute per milligram, when measured with an end-window type of Geiger–Müller counter and a scale of 128.
Access options
Subscribe to Journal
Get full journal access for 1 year
$199.00
only $3.90 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.
References
- 1
Campbell, H. A., and Link, K. P., J. Biol. Chem., 138, 21 (1941).
- 2
Shapiro and Weiner, “Coagulation, Thrombosis and Dicumarol”.
- 3
Lee, Trevoy, Jaques and Spinks, Can. J. Res. (in the press).
Author information
Affiliations
Departments of Chemistry and Physiology, University of Saskatchewan, Saskatoon, Sask.
- J. W. T. SPINKS
- & L. B. JAQUES
Authors
Search for J. W. T. SPINKS in:
Search for L. B. JAQUES in:
Rights and permissions
To obtain permission to re-use content from this article visit RightsLink.
About this article
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
