Letter | Published:

Tracer Experiments in Mammals with Dicumarol Labelled with Carbon-14

Naturevolume 166page184 (1950) | Download Citation



DICUMAROL1 is widely used clinically for the treatment of thrombosis. Since very little is known about the mechanism whereby dicumarol lowers the prothrombin-level in blood2, it was thought that experiments with dicumarol labelled with carbon-14 might be of value. The dicumarol was prepared by adding an aqueous solution of formaldehyde containing carbon-14, obtained from the Oak Ridge National Laboratory, to a saturated aqueous solution of 4-hydroxycoumarin3. The 3,3′-methylene-C14-bis(4-hydroxycoumarin) so obtained had a specific activity of 6 × 104 counts per minute per milligram, when measured with an end-window type of Geiger–Müller counter and a scale of 128.

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  1. 1

    Campbell, H. A., and Link, K. P., J. Biol. Chem., 138, 21 (1941).

  2. 2

    Shapiro and Weiner, “Coagulation, Thrombosis and Dicumarol”.

  3. 3

    Lee, Trevoy, Jaques and Spinks, Can. J. Res. (in the press).

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  1. Departments of Chemistry and Physiology, University of Saskatchewan, Saskatoon, Sask.

    • J. W. T. SPINKS
    •  & L. B. JAQUES


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