Abstract
DICUMAROL1 is widely used clinically for the treatment of thrombosis. Since very little is known about the mechanism whereby dicumarol lowers the prothrombin-level in blood2, it was thought that experiments with dicumarol labelled with carbon-14 might be of value. The dicumarol was prepared by adding an aqueous solution of formaldehyde containing carbon-14, obtained from the Oak Ridge National Laboratory, to a saturated aqueous solution of 4-hydroxycoumarin3. The 3,3′-methylene-C14-bis(4-hydroxycoumarin) so obtained had a specific activity of 6 × 104 counts per minute per milligram, when measured with an end-window type of Geiger–Müller counter and a scale of 128.
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References
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SPINKS, J., JAQUES, L. Tracer Experiments in Mammals with Dicumarol Labelled with Carbon-14. Nature 166, 184 (1950). https://doi.org/10.1038/166184a0
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DOI: https://doi.org/10.1038/166184a0
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