Letter | Published:

Vitamin B12 as an Anti-Anaphylactic

Naturevolume 166pages7879 (1950) | Download Citation



FOLLOWING the pure hypothesis that macrocytic anæmias could be due to an anaphylactic blockage of the bone marrow, especially as regards erythropoiesis, it was supposed that folic acid, the action of which in these anæmias has been of some help, might have an anti-anaphylactic action. Experiments were therefore performed which showed folic acid to possess a protective action on the anaphylaxis of the guinea pigs1. I thought it would be interesting to see whether such an anti-anaphylactic action might be shown also by vitamin B12, which has turned out to be very effective, even in a very small dosage, in the treatment of pernicious and some other macrocytic anæmias2–4.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Traina, V., Nature, 163, 364 (1949).

  2. 2

    Hall, B. E., and Campbell, D. C., Proc. Staff Meet., Mayo Clin., 23, 584 (1948).

  3. 3

    Hall, B. E., and Campbell, D. C., Proc. Staff Meet., Mayo Clin., 23, 591 (1948).

  4. 4

    Spies, T. D., Stone, R. E., Garcia Lopez, G., Milanes, F., Lopez Toca, R., and Aramburu, T., Lancet, ii, 519 (1948).

  5. 5

    Berk, L., Denny Brown, D., Finland, M., and Castle, W. B., New Eng. J. Med., 239, 328 (1948).

  6. 6

    Marcus, S., Proc. Soc. Exp. Biol. and Med., 66, 181 (1947).

  7. 7

    Traina, V., and Alekdandrowicz, D., Nature, 163, 364 (1949).

  8. 8

    Friedlander, F., Feinberg, S. M., and Feinberg, A. R., Proc. Soc. Exp. Biol. and Med., 62, 65 (1946).

  9. 9

    Loew, E. R., and Kaiser, M. E., Proc. Soc. Exp. Biol. and Med., 58, 235 (1945).

Download references

Author information


  1. Fairview Park Hospital, Cleveland, 13, Ohio



  1. Search for VINCENZO TRAINA in:

About this article

Publication history

Issue Date




By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.