Letter | Published:

Vitamin B12 as an Anti-Anaphylactic

Nature volume 166, pages 7879 (08 July 1950) | Download Citation

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Abstract

FOLLOWING the pure hypothesis that macrocytic anæmias could be due to an anaphylactic blockage of the bone marrow, especially as regards erythropoiesis, it was supposed that folic acid, the action of which in these anæmias has been of some help, might have an anti-anaphylactic action. Experiments were therefore performed which showed folic acid to possess a protective action on the anaphylaxis of the guinea pigs1. I thought it would be interesting to see whether such an anti-anaphylactic action might be shown also by vitamin B12, which has turned out to be very effective, even in a very small dosage, in the treatment of pernicious and some other macrocytic anæmias2–4.

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Affiliations

  1. Fairview Park Hospital, Cleveland 13, Ohio.

    • VINCENZO TRAINA

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DOI

https://doi.org/10.1038/166078b0

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