Abstract
FOLLOWING the suggestion of Dewar1, it is now generally accepted that the mould metabolic products, stipitatic acid, puberulic acid and puberulonic acid are derivatives of tropolone2. Erdtman and Gripenberg3 have shown that α-, β- and γ-thujaplicins from Thuja plicata, the western red cedar tree, are, respectively, α-, β- and γ-isopropyltropolones. γ-Thujaplicin was found to possess fungicidal activity; when spores of Pullularia pullulans were suspended in a 0.02 per cent solution, 100 per cent survived after 1 hr., 11 per cent after 3 hr. and none after 6 hr. and 24 hr. exposure. Two of us (J. W. C. and A. R. S.) have recently described a synthesis of 3 : 4-benztropolone4.
Similar content being viewed by others
Article PDF
References
Dewar, M. J. S., Nature, 155, 50 (1945).
See Corbett, R. E., Hassall, C. H., Johnson, A. W., and Todd, A. R., Chem. and Indust., 626 (1949).
Erdtman, H., and Gripenberg, J., Nature, 161, 719 (1948). Erdtman, H., Anderson, A .B., and Gripenberg, J., Acta Chem. Scand., 2, 625, 639, 644 (1948).
Cook, J. W., and Somerville, A. R., Nature, 163, 410 (1949).
Freeman, G. G., and Morrison, R. I., Nature, 162, 30 (1948).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BAILLIE, A., FREEMAN, G., COOK, J. et al. Antibacterial and Antifungal Activity of Benztropolone. Nature 166, 65 (1950). https://doi.org/10.1038/166065a0
Issue Date:
DOI: https://doi.org/10.1038/166065a0
This article is cited by
-
An ecological life history of Aureobasidium pullulans (de Bary) Arnaud
Mycopathologia et Mycologia Applicata (1959)
-
�ber die bakteriostatische Wirkung einiger Tropolonverbindungen und das Verhalten der bakteriellen Resistenz gegen dieselben
Klinische Wochenschrift (1953)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.