Letter | Published:

Direct Oxidation of Glucose-6-Phosphate by Animal Tissues

Naturevolume 166page33 (1950) | Download Citation



YEAST1–4 and red blood cells5 contain enzyme systems which require coenzyme II and are capable of oxidizing glucose-6-phosphate to 6-phosphogluconic acid. The oxidation can also proceed further1,3,6, and evidence has been presented that in yeast stepwise C1- and C2-oxidation and decarboxylation may proceed via a pentose phosphoric ester; this was considered to be D-ribose-5-phosphate rather than D-arabinose-5-phosphate, which, although it has the configuration of D-glucose, is not attacked by yeast enzymes6. Further support for this view has recently been provided by the chromatographic identification of 2-ketogluconate and D-ribose-5-phosphate among the oxidation products of 6-phosphogluconic acid7.

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    Cohen, S. S., and McNair Scott, D. B., Science, 111, 513 (1950).

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    Barkhash, A. P., and Demianovskaya, N. S., C.R. Acad. Sci., URSS., 54, 423 (1946). Lindberg, O., Arkiv. Kemi, Mineral. Geol., A23, No. 2, 1 (1947). Wainio, W. W., J. Biol. Chem., 168, 569 (1947).

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  1. Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, London, W.1

    • F. DICKENS


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