Letter | Published:

Biological Assay of Small Quantities of Desoxycorticosterone Acetate

Naturevolume 166pages3233 (1950) | Download Citation



ALTHOUGH early studies on the adrenalectomized dog1 have led to means of assay for desoxycorticosterone acetate and for extracts of the adrenal cortex in quantity2–4, no satisfactory micro-assay has hitherto been described.

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    Loeb, R. F., Atchley, D. W., Benedict, E. M., and Leland, J., J. Exp. Med., 57, 775 (1933).

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    Hartman, F. A., and Spoor, H. J., Endocrin., 26, 871 (1940).

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    Harrop, G. A., and Thorn, G. W., J. Exp. Med., 65, 757 (1937)

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    Hartman, F. A., Lewis, L. A., and Thatcher, J., Proc. Soc. Exp. Biol. Med., 48, 60 (1941).

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    Spencer, A. G. (in the press).

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    Berry, J. W., Chappell, D. G., and Barnes, R. B., Indust. and Eng. Chem. (Anal. Edit.), 18, 19 (1946).

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    Bliss, C. I., Indust. Eng. Chem., 12, 84 (1941).

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  1. Departments of Medicine of the College of Physicians and Surgeons, New York

    • A. G. SPENCER
  2. University College Hospital Medical School, London, W.C.1

    • A. G. SPENCER


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