Arterenol Content of the Mammalian and Human Adrenal Medulla

Abstract

Holtz, Credner and Kroneberg1 some years ago showed that in human urine there is a sympathetic pressor substance called by them ‘urosympathin’. In patients with essential hypertension, ‘urosympathin’ was secreted in larger quantities than in normal individuals. The active substance isolated by absorption on aluminium hydroxide and elution with sodium dihydrogen phosphate was evaluated against adrenaline using the blood pressure of the cat for assay. A dose of ‘urosympathin’ equal in this assay to a certain amount of adrenaline had a Weaker effect on the blood pressure of the rabbit and on the isolated rabbit intestine. Contrary to adrenaline, its pressor effect was not reversed by sympathicolytics but only weakened. Polyphenoloxidase destroyed its activity. Where the ‘urosympathin’ differed pharmacologically from adrenaline, it resembled the demethylated derivative nor-adrenaline or arterenol. Experiments2 not yet published showed that the ‘urosympathin’ of animals' urine also contains arterenol as chief constituent.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Holtz, P., Credner, K., and Kroneberg, G., Arch. exp. Path. u. Pharmakol., 204, 228 (1944–47).

  2. 2

    Holtz, P., Kroneberg, G., and Schümann, H. J., Arch. exp. Path. u. Pharmakol. (in the press).

  3. 3

    Euler, U. v., Acta physiol. Scand., 11, 168 (1946) ; 12, 73 (1946) ; 16, 63 (1948).

  4. 4

    Holtz, P., Verhandl. deutsch. Physiol. Ges., Frankfurt (1948). Schümann, H. J., Klin. Wschr., 605 (1948); Arch. exp. Path. u. Pharmakol., 206, 475 (1949). Holtz, P., and Schümann, H. J., Naturw., 159 (1948); Arch. exp. Path. und Pharmakol., 206, 484 (1949).

  5. 5

    Schümann, H. J., Arch. exp. Path. u. Pharmakol., 206, 164, 475 (1949).

  6. 6

    Holtz, P., Schümann, H. J., Langenbeck, W., and LeBlanc, H., Naturw., 191 (1948).

  7. 7

    Tullar, B. F., Science, 109, 536 (1939).

  8. 8

    Bergström, S., v. Euler, U. S., and Hamberg, U., Act. chem. Scand., 3, 305 (1949).

  9. 9

    Gaddum, J. H., and Kwiatowski, H., J. Physiol., 96, 385 (1939).

  10. 10

    Kroneberg, G. (unpublished results).

  11. 11

    Shaw, F. H., Biochem. J., 32, 19 (1938).

  12. 12

    Holtz, P., Klin. Wschr., 64 (1949).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

HOLTZ, P., SCHÜMANN, H. Arterenol Content of the Mammalian and Human Adrenal Medulla. Nature 165, 683 (1950) doi:10.1038/165683a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.