Frequency of Microcythæmia in some Italian Districts


IT has been demonstrated1 that ‘microcythæmia’ or ‘thalasshæmia’ depends on a single gene pair with semi-dominance. The heterozygotes Mm are microcythæmics, that is, entirely viable individuals, either normal, or suffering from a mild form of anhæmia. The homozygotes MM, on the contrary, are affected by Cooley's disease and die early in childhood. The two forms are also called by American authors ‘thalasshæmia minor’ (Mm), and ‘thalasshæmia major’ (MM).

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  1. 1

    Silvestroni, E., and Bianco, I., Boll. Atti R. Accad. Med. Roma, 69, 293 (1943–44) ; Policlinico, Sez. Med., 52, 105 and 137 (1945) ; Policlinico, Sez. Prat., 54, 1359 (1947) ; Min. Med., 2, 206 (1946). Valentine, W. N., and Neel, J. V., Arch. Int. Med., 74, 185 (1944). Neel, J. V., and Valentine, W. N., Genetics, 32, 38 (1947).

  2. 2

    Silvestroni, E., and Bianco, I., Policlinico, Sez. Med., 52, 105 and 137 (1945) ; Ric. Scient. Ricostr., 17, 655 and 2021 (1947) ; Policlinico, Sez. Prat., 55, 417 (1948) ; Min. Med., 1, 205 (1948) ; Ric. Scient. Ricostr., 19, 230 (1949) ; Policlinico, Sez. Prat., 56, 602 and 906 (1949).

  3. 3

    Haldane, J. B. S., Proc. Roy. Soc., B, 135, 147 (1948).

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SILVESTRONI, E., BIANCO, I., MONTALENTI, G. et al. Frequency of Microcythæmia in some Italian Districts. Nature 165, 682–683 (1950).

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