Fluoroacetate and the Tricarboxylic Acid Cycle in Nematode Parasites

Abstract

CONCEPTIONS of the mode of action of fluoroacetate are varied and conflicting, according to the biological material studied1–5. Another reaction of fluoroacetate, in nematode parasites, in which it appears to inhibit oxidation within the Krebs tricarboxylic acid cycle, is reported here.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Bartlett, G. R., and Barron, E. S. G., J. Biol. Chem., 170, 67 (1947).

  2. 2

    Kalnitsky, G., and Barron, E. S. G., J. Biol. Chem., 170, 83 (1947).

  3. 3

    Kalnitsky, G., and Barron, E. S. G., Archiv. Biochem., 19, 75 (1948).

  4. 4

    Bueding, E., J. Exp. Med., 89, 107 (1949).

  5. 5

    Black, S., and Hutchens, J. C., Archiv. Biochem., 17, 211 (1948).

  6. 6

    Pucher, G. W., Sherman, C. C., and Vickery, H. B., J. Biol. Chem., 113, 235 (1936).

  7. 7

    Krebs, H. A., and Eggleston, F., Biochem. J., 38, 426 (1944).

  8. 8

    Seevers, M. H., and Shideman, F. E., Science, 94, 351 (1941).

  9. 9

    Massey, V., and Rogers, W. P., Aust. J. Sci. Res., B (in the press).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

MASSEY, V., ROGERS, W. Fluoroacetate and the Tricarboxylic Acid Cycle in Nematode Parasites. Nature 165, 681–682 (1950). https://doi.org/10.1038/165681b0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.