Hæmolytic Complement and Ascorbic Acid


IN a recent communication, Traina1 described the anti-hæmolytic effect of vitamin C in complement and saponin hæmolysis systems. Investigations conducted thirteen years ago2 showed that while ascorbic acid in high concentration had an inhibitory effect on complement activity, hæmolysis by complement was enhanced by low concentrations.

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  1. 1

    Traina, V., Nature, 164, 843 (1949).

  2. 2

    Bernstein, R. E., Studies on Hæmolytic Complement, M.Sc. thesis, University of the Witwatersrand (1937).

  3. 3

    Osborn, T. W. B., “Complement or Alexin” (Oxford Univ. Press, 1937).

  4. 4

    Ecker, E. E., Pillemer, L., Wertheimer, D., and Gradis, H., J. Immunol., 34, 19 (1938).

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BERNSTEIN, R. Hæmolytic Complement and Ascorbic Acid. Nature 165, 607 (1950) doi:10.1038/165607a0

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