Change in Kidney Tubule Functions on a Diet Poor in Sodium Chloride


WHEN normal individuals are put on a diet poor in sodium chloride, the urinary output falls to very low levels within a few days. This happens although the serum sodium and glomerular filtration-rate are reduced only slightly, a consideration which led us to question the emphasis laid by Wesson et al.1 on sodium load as the major determinant of sodium excretion. Their view that small variations in serum sodium and in glomerular filtration-rate account for variations in sodium excretion is difficult to test, since the variations they postulate are inaccessible to the methods available for determining glomerular filtration-rate and serum sodium.

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  1. 1

    Wesson, L. G., Anslow, W. P., and Smith, H. W., Bull. N.Y. Acad. Med., 24, 586 (1948).

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BLACK, D., PLATT, R. & STANBURY, S. Change in Kidney Tubule Functions on a Diet Poor in Sodium Chloride. Nature 165, 605–606 (1950) doi:10.1038/165605a0

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