Histochemical Study of Fat Deposits in Chronic Intoxication of the Dog by γ-Hexachlorocyclohexane

Abstract

CHRONIC intoxication of dogs by the γ-isomer of hexachlorocyclohexane was induced by repeated intramuscular injections of 10–30 mgm. of this substance in 10 per cent oily solution per kgm body-weight, until a total dose of 130–475 mgm./kgm. was reached. The dogs died or were killed seven to forty-four days after the first injection. The intoxication resulted in abnormal intracellular deposits of fat in most tissues and organs.

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GEREBTZOFF, M., DALLEMAGNE, M. & PHILIPPOT, E. Histochemical Study of Fat Deposits in Chronic Intoxication of the Dog by γ-Hexachlorocyclohexane. Nature 165, 572–573 (1950). https://doi.org/10.1038/165572b0

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