Synthesis of Hydrastine


CONDENSATION of nitromeconine and hydrastinine gave a mixture of nitrohydrastines, which was reduced and the product separated into aminohydrastines-a and -b 1. By the removal of the ammo-groups, dl-hydrastine-a (m.p. 137°) and dl-hydrastine-b (m.p. 150–51°) were obtained, but at that time neither of these inactive stereoisomerides could be resolved.

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    Hope and Robinson, Proc. Chem. Soc., 28, 17 (1912). Hope, Pyman, Remfry and Robinson, J. Chem. Soc., 236 (1931).

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    Marshall, Pyman and Robinson, J. Chem. Soc., 1315 (1934).

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    Cf. Perkin, Rây and Robinson, J. Chem. Soc., 127, 740 (1925).

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    Groenewoud and Robinson, J. Chem. Soc., 199 (1936).

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HAWORTH, R., PINDER, A. & ROBINSON, R. Synthesis of Hydrastine. Nature 165, 529 (1950) doi:10.1038/165529a0

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