SINCE evidence has been accumulated that a release of histamine, or histamine-like substances, accounts, completely or partially, for anaphylactic shock in animals1, an attempt has been made to find out whether vitamin B12, which has been shown to possess a protective action on anaphylactic shock in the guinea pig2, could also have an anti-histaminic activity. Vitamin B12 has therefore been tested on guinea pigs in which a histaminic shock was provoked ; as source of vitamin B12, ‘Rubramin’ (Squibb) vials of 15 γ have been used.
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TRAINA, V. Vitamin B12 and Histamine. Nature 165, 439–440 (1950). https://doi.org/10.1038/165439b0
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