OUR knowledge of the amino-acid composition of Bence–Jones protein is still incomplete. Recently, Dent1 has analysed a specimen of Bence–Jones protein, using paper partition chromatography, with regard to its amino-acid composition. He found that the specimen contained all the common amino-acids except methionine and hydroxyproline. Dent's findings were at variance with those of Devine2, who found methionine present in amount 0.58 per cent.
Dent, C. E., and Rose, C. A., Proc. Biochem. Soc. (December 1948).
Devine, J., Biochem. J., 35, 433 (1941).
Consden, R., Gordon, A. H., and Martin, A. J. P., Biochem. J., 38, 224 (1944).
Feigl, F., "Quantitative Analysis by Spot Tests", 354 (Blaevier, New York, 1947).
Waldenström, J., Acta Med. Scand., 117, 215 (1944).
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PAPASTAMATIS, S., KENCH, J. & WILKINSON, J. Amino-acid Composition of Bence–Jones Protein. Nature 164, 961 (1949). https://doi.org/10.1038/164961a0
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