Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Nature of the Circulating Thyroid Hormone


Taurog and Chaikoff1 have presented strong evidence in support of the view that in the normal animal the circulating thyroid hormone consists of thyroxine loosely attached to plasma protein. They observed in rat plasma that the protein-bound iodine labelled with radioactive iodine (I131) followed thyroxine carrier quantitatively when the latter was crystallized repeatedly, or when it was distributed between two immiscible solvents. In the experiments to be described, confirmation of this work has been obtained by the use of paper partition chromatography2.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout


  1. Taurog, A., and Chaikoff, I. L., J. Biol. Chem., 176, 639 (1948).

    CAS  PubMed  Google Scholar 

  2. Fink, R. M., Dent, C. E., and Fink, K., Nature, 160, 801 1947

    Article  ADS  CAS  Google Scholar 

  3. Hird, F. J. R., and Trikojus, V. M., Aust. J. Sci., 10, 185 (1948).

    CAS  PubMed  Google Scholar 

  4. Jones, H. B., U.S. Atomic Energy Commission, Nuclear Science Abstracts, 1, 216 (1948).

Download references

Author information

Authors and Affiliations

Author notes

  1. Alfred Stengel Research Fellow of the American College of Physicians 1949-50.


    Rights and permissions

    Reprints and Permissions

    About this article

    Cite this article

    LAIDLAW, J. Nature of the Circulating Thyroid Hormone. Nature 164, 927–928 (1949).

    Download citation

    • Issue Date:

    • DOI:

    This article is cited by


    By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


    Quick links

    Nature Briefing

    Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

    Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing