Taurog and Chaikoff1 have presented strong evidence in support of the view that in the normal animal the circulating thyroid hormone consists of thyroxine loosely attached to plasma protein. They observed in rat plasma that the protein-bound iodine labelled with radioactive iodine (I131) followed thyroxine carrier quantitatively when the latter was crystallized repeatedly, or when it was distributed between two immiscible solvents. In the experiments to be described, confirmation of this work has been obtained by the use of paper partition chromatography2.
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Taurog, A., and Chaikoff, I. L., J. Biol. Chem., 176, 639 (1948).
Fink, R. M., Dent, C. E., and Fink, K., Nature, 160, 801 1947
Hird, F. J. R., and Trikojus, V. M., Aust. J. Sci., 10, 185 (1948).
Jones, H. B., U.S. Atomic Energy Commission, Nuclear Science Abstracts, 1, 216 (1948).
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LAIDLAW, J. Nature of the Circulating Thyroid Hormone. Nature 164, 927–928 (1949). https://doi.org/10.1038/164927a0
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