Cook, Heilbron and Levy1 have recently prepared tetraglycylglycine and several di-peptides by reaction of 2-thio-5-thiazolones with amino-acid derivatives. During the past few years, much interest has also been shown in the polymerization potentialities of the N-carboxy anhydrides of α-amino-acids2–5. Study of the reaction of these anhydrides with simple organic bases has now indicated the mechanism of their polymerization and provided a new method of building up polypeptides by addition of single amino-acid units.
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BAILEY, J. A New Peptide Synthesis. Nature 164, 889 (1949). https://doi.org/10.1038/164889a0
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