IT has been argued that the concentration of sugar (or glycogen) within a tissue is a critical factor in controlling the rate of mitosis1. An abundance of sugar induces active cell division, while a sugar deficiency results in mitosis depression. Such a depression follows treatment with insulin, which lowers the blood sugar level ; phloridzin, which interferes with phosphorylation ; and starvation, which depletes the carbohydrate reserves of the whole body.
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Bullough, W. S., Nature, 163, 680 (1949).
Green, H. N., and Stoner, H. B., "Biological Actions of the Adenine Nucleotides" (London: H. K. Lewis and Co., Ltd., in the press).
Bullough, W. S., Proc. Roy. Soc., B, 135, 212 (1948).
Green, H. N., Lancet, ii, 147 (1943).
Bielschowsky, M., and Green, H. N., Lancet, ii, 153 (1943).
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BULLOUGH, W., GREEN, H. Shock and Mitotic Activity in Mice. Nature 164, 795–796 (1949). https://doi.org/10.1038/164795b0
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