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Shock and Mitotic Activity in Mice


IT has been argued that the concentration of sugar (or glycogen) within a tissue is a critical factor in controlling the rate of mitosis1. An abundance of sugar induces active cell division, while a sugar deficiency results in mitosis depression. Such a depression follows treatment with insulin, which lowers the blood sugar level ; phloridzin, which interferes with phosphorylation ; and starvation, which depletes the carbohydrate reserves of the whole body.

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  1. Bullough, W. S., Nature, 163, 680 (1949).

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  2. Green, H. N., and Stoner, H. B., "Biological Actions of the Adenine Nucleotides" (London: H. K. Lewis and Co., Ltd., in the press).

  3. Bullough, W. S., Proc. Roy. Soc., B, 135, 212 (1948).

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  4. Green, H. N., Lancet, ii, 147 (1943).

  5. Bielschowsky, M., and Green, H. N., Lancet, ii, 153 (1943).

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BULLOUGH, W., GREEN, H. Shock and Mitotic Activity in Mice. Nature 164, 795–796 (1949).

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