INVESTIGATIONS by A. R. Todd1, H. Rinderknecht2, W. B. Geiger3 and others have shown that many unsaturated ketones with the grouping —C = C—CO—, also present in a number of naturally occurring antibiotics, possess antibacterial action. In our studies on unsaturated ketones, we found that chalkone, flavanone, flavone and some of their derivatives, for example, buteine (2,4,3',4'-tetrahydroxychalkone). a substance of vegetable origin, showed a marked inhibition of the growth of Staph. aureus. Also extracts of plants containing flavanones, flavones or flavonoles were found to be bacteriostatic4. Furthermore, we have prepared a number of synthetic chalkones of which some compounds suppressed the growth at high dilutions.
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Rinderknecht, H., Ward, J. L., Bergel, F., and Morrison, A. L., Biochem. J., 41, 463 (1947).
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Schraufstätter, E., Richter, R., and Ditseheid, W., Arch. f. Dermatol. u. Syph., 188, 259 (1949).
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SCHRAUFSTÄTTER, E., BERNT, H. Antibacterial Action of Curcumin and Related Compounds. Nature 164, 456–457 (1949). https://doi.org/10.1038/164456a0
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