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Reactivity of 4-Substituted Heterocyclic Nitrogen Compounds

Abstract

FOR some considerable time we have been engaged in a study of the relative reactivities of derivatives of cinnoline, quinazoline and quinoline containing a series of identical substituents attached to C4. Although the results of this work appeared to be clear-cut and to lead to certain clearly formulated conclusions, they were nevertheless equivocal in so far as they were essentially based on qualitative or semi-quantitative observations and not on kinetic measurements.

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References

  1. Longuet-Higgius and Coulson, J. Chem. Soc., 971 (1949).

  2. Keneford, Morley, Simpson, Wright, J. Chem. Soc., 1356 (1949)

  3. Atkinson and Simpson, J. Chem. Soc., 808 (1947).

  4. Simpson, J. Chem. Soc., 1653 (1947).

  5. Morley and Simpson, J. Chem. Soc., 360 (1948); 1354 (1949).

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MORLEY, J., SIMPSON, J. Reactivity of 4-Substituted Heterocyclic Nitrogen Compounds. Nature 164, 1051–1052 (1949). https://doi.org/10.1038/1641051b0

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