Abstract
REDUCTION of methoxybenzene derivatives by the sodium–ammonia–alcohol reagent followed by acid hydrolysis leads to the formation of a number of hitherto inaccessible unsaturated ketones1. The process fails with some compounds because of their insolubility in liquid ammonia, a typical example being hexæstrol dimethyl ether (I, R = CH3). This substance has been treated under a variety of conditions and with admixed solvents, for example, ether or ethylenediamine, but so far without success.
Similar content being viewed by others
Article PDF
References
Birch, J. Chem. Soc., 593 (1946).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BIRCH, A., MUKHERJI, S. Reduction by Sodium – Ammonia Solutions. Nature 163, 766 (1949). https://doi.org/10.1038/163766a0
Issue Date:
DOI: https://doi.org/10.1038/163766a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.