WHEN infected intravenously, suramin (synonyms: 'Antrypol : Bayer 205 ; 'Germanin' : Fourneau/309) quickly effects the removal of try-panosopfes from the blood and tissues of man and other^nimals suffering from sleeping sickness due to Trypanosoma gambiense or T. rhodesiense infections, if the infection is not too far advanced. The precise way in which suramin exerts its specific action on the trypanosome or on the defence mechanisms of the host or on both is still unknown, although several theories have been advanced1.
See review of the literature by Findlay, G. M., "Recent Advances in Chemotherapy" (J. and A. Churchill, 2nd edition, 1939).
Yorke, W., Adams, A. R. D., and Murgatroyd, F., Ann. Trop. Med. Parasitol., 23, 501 (1929); 24, 115 (1930).
Beilinsohn, A., Zhurnal Exp. Biol. Med., 11, 52 (1929); cited from Chem. Abstr., 24, 1427 (1930).
Quastel, J. H., Biochem. J., 25, 1121 (1931).
Fürth, O., Scholl, R., and Herrmann, H., Wien. klin. Woch., 45, 1012 (1932).
Stuber, B., and Lang, K., Biochem. Z., 179, 70 (1926); cf., however, Tcherniakofsky, P., and Nattan-Larrier, R., C.R. Soc. Biol., 126, 1070 (1937).
Beiler, J. M., and Martin, C. J., J. Biol. Chem., 174, 31 (1948).
Wilson, E. J., and Wormall, A., (in the press).
Spinks, A., Biochem. J., 42, 109 (1948).
Boursnell, J. C., and Wormall, A., Biochem. J., 33, 1191 (1939); Dewey, H. M., and Wormall, A., ibid., 40, 119 (1946).
Dangerfield, W. G., Gaunt, W. E., and Wormall, A., Biochem. J., 32, 59 (1938); cf. also Vierthaler, R. W., and Boselli, A., Arch. Schiffs-u. Tropenhyg., 42, 149 (1939); Spinks, A., reference 9.
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TOWN, B., WILLS, E. & WORMALL, A. Action of Suramin on Enzymes. Nature 163, 735–736 (1949). https://doi.org/10.1038/163735a0
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