Effect of Enzyme Inhibitors on the Genesis of Phage

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IT is generally agreed that the multiplication of viruses is intimately linked with the metabolism of the host cell1. It seemed, therefore, interesting to study the influence of enzyme inhibitors on the development of virus within the host cell. In this connexion we have launched an extensive investigation with regard to the influence of enzyme inhibitors on the growth of the bacterial cell and the development of 'bacterial virus' particles respectively.

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    Foster, C., Jones, J. H., Henle, W., and Dorfman, W., J. Exp. Med., 79, 221 (1944). Friedewald, W. F., J. Exp. Med., 75, 197 (1942). Parker, R. F., and Thompson, R. L., J. Exp. Med., 75, 567 (1942). Rasmussen, jun., A. F., Waisman, H. A., Elvehjem, C. A., and Clark, P. F., J. Infect. Dis., 74, 41 (1944). Sprunt, D. H., J. Exp. Med., 75, 297 (1942). Toomey, J. A., Frohring, W. O., and Takacs, W. S., Yale J. Biol. Med., 16, 477 (1944).

  2. 2

    Dolby, D. E., and Czekalowski, J. W., Nature [163, 608 (1949)].

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CZEKALOWSKI, J., DOLBY, D. Effect of Enzyme Inhibitors on the Genesis of Phage. Nature 163, 719–720 (1949) doi:10.1038/163719b0

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