Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Action of Thiosulphate on the Kidney of the Cat


SODIUM thiosulphate has recently been recommended as a substance suitable for use in measuring the glomerular filtration-rate (G.F.R.) in the kidney. Its concentration in blood and urine is easily and reliably measured, it is neither re-absorbed nor secreted by the tubule cells in man1 or dog2,3, and is stated, to be non-toxic. In the cat it behaves very differently. It is actively secreted, that is, its clearance is higher than that of creatinine, which is a measure of the glomerular filtration-rate, and its clearance rises with falling concentration in the plasma, as can be seen in Fig. 1 This finding confirms the recent suggestion of Bing and Effersøe4.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others


  1. Newman, E. V., Gilman, A., and Philips, F. S., Johns Hopkins Hosp. Bull., 79, 229 (1946).

    CAS  Google Scholar 

  2. Gilman, A., Philips, F. S., and Koelle, E. S., Amer. J. Physiol., 146, 348 (1946).

    Article  CAS  Google Scholar 

  3. Pitts, R. F., and Lotspeich, W. D., Proc. Soc. Exp. Biol., N.Y., 64, 224 (1947).

    Article  CAS  Google Scholar 

  4. Bing, J., and Effers e, P., Acta physiol. Scand., 15, 231 (1948).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

EGGLETON, M., HABIB, Y. Action of Thiosulphate on the Kidney of the Cat. Nature 163, 1000–1001 (1949).

Download citation

  • Issue Date:

  • DOI:


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing