Abstract
UP to the present, experimental methods have yielded very little information concerning vestibular toxicity due to streptomycin ; in medical practice these accidents are very frequent (80–90 per cent of cases treated). Indeed, the fundamental work of Molitor and his collaborators leads to the conclusion that most of the animals used in laboratory work show no recognizable vestibular disturbance, whether as the result of a single heavy dose of streptomycin or of several fractional doses administered over a period of time. According to Molitor1, dogs are the only animals which show any evidence of cerebellar or vestibular damage comparable to that which has been observed in human beings, whereas mice, frogs, rats and guinea pigs are unaffected. Although Molitor kept under observation a considerable number of animals, we believe that his conclusions should not be accepted as final.
Similar content being viewed by others
Article PDF
References
Molitor, H., Graessle, O. E., Kuna, S., Mushett, C. W., and Silber R. H., J. Pharm. Exp. Therap., 86, 151 (1946).
Magnus, R., "Körperstellung" (Berlin, 1924).
Cf. C.R. Soc. Biol., 142, 45 (1948).
Ehrlich, P., Berl. Klin. Wochens., 44, 280 (1907).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CAUSSÉ, R., GONDET, I. & VALLANCIEN, B. Vestibular Effect of Streptomycin in the Mouse. Nature 162, 929 (1948). https://doi.org/10.1038/162929a0
Issue Date:
DOI: https://doi.org/10.1038/162929a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.