Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Effects upon tumours of Various Haloalkylarylamines


IN an extension of work upon the growth-inhibitory and carcinogenic effects of 4-aminostilbene1, special attention has been devoted to the influence on these properties of varying the basic side-chain. In one series, the compound 4-NN-di(2-chloroethyl) aminostilbene was of interest as containing the chloroethyl groupings characteristic of the nitrogen mustards. Administration of this substance in relatively high dosage (c. 500 mgm./kgm.) to rats bearing the Walker carcinoma, in an orienting type of experiment already described1, produced an inhibition of tumour-growth considerable in degree but of very brief duration; and pharmacologically the compound appeared, not surprisingly, to be markedly different from the aliphatic chloroethyl -amines on one hand and the aminostilbenes on the other.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Haddow, A., Harris, R. J. C., Kon, G. A. R., and Roe, Edna, M. F., Phil Trans. Roy. Soc., A, 241 147 (1948).

    Article  ADS  Google Scholar 

  2. Ross, W. C. J., J. Chem. Soc. (in the press).

  3. Ross, S. D., J. Amer. Chem. Soc., 69, 2982 (1947).

    Article  CAS  Google Scholar 

  4. Hanby, W. E., Hartley, G. S., Powell, E. O., and Rydon, H. N., J. Chem. Soc., 519 (1947).

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

HADDOW, A., KON, G. & ROSS, W. Effects upon tumours of Various Haloalkylarylamines. Nature 162, 824–825 (1948).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing