Effects upon tumours of Various Haloalkylarylamines

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Abstract

IN an extension of work upon the growth-inhibitory and carcinogenic effects of 4-aminostilbene1, special attention has been devoted to the influence on these properties of varying the basic side-chain. In one series, the compound 4-NN-di(2-chloroethyl) aminostilbene was of interest as containing the chloroethyl groupings characteristic of the nitrogen mustards. Administration of this substance in relatively high dosage (c. 500 mgm./kgm.) to rats bearing the Walker carcinoma, in an orienting type of experiment already described1, produced an inhibition of tumour-growth considerable in degree but of very brief duration; and pharmacologically the compound appeared, not surprisingly, to be markedly different from the aliphatic chloroethyl -amines on one hand and the aminostilbenes on the other.

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References

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    Haddow, A., Harris, R. J. C., Kon, G. A. R., and Roe, Edna, M. F., Phil Trans. Roy. Soc., A, 241 147 (1948).

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    Ross, W. C. J., J. Chem. Soc. (in the press).

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    Ross, S. D., J. Amer. Chem. Soc., 69, 2982 (1947).

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    Hanby, W. E., Hartley, G. S., Powell, E. O., and Rydon, H. N., J. Chem. Soc., 519 (1947).

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