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Production of Indole by Escherichia coli

Nature volume 162, pages 229231 (07 August 1948) | Download Citation

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Abstract

THE mechanism of the production of indole by Escherichia coli has attracted the attention of many workers since Hopkins and Cole1 first demonstrated that the precursor of indole is tryptophan. The problem is an intriguing one among the bacterial degradation of amino-acids, inasmuch as fission of a carbon-carbon bond occurs at a position in the molecule remote from the amino- and carboxyl-groups, instead of the more usual carbon-nitrogen split. It became even more intriguing when an exhaustive survey of theoretically possible intermediates in the reaction failed to give rise to indole in the presence of the organism.

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Affiliations

  1. Department of Biochemistry, University of Leeds

    • EDWIN A. DAWES

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DOI

https://doi.org/10.1038/162229a0

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