A Natural Precursor of the Folic Acid Complex

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Abstract

RECENTLY Elvehjem and his co-workers1 have demonstrated the presence, in rat liver homogenates, of a natural precursor capable of conversion by enzymes also present in liver to material having folic acid activity. They base the use of the term ‘folic acid' on the fact that there is no evidence that the material produced is identical with pteroylglutamic acid. The same considerations apply to its use in the present communication.

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References

  1. 1

    Olson, O. E., Fager, E. E. C., Buris, R. H., and Elvehjem, C. A., J. Biol. Chem., 174, 319 (1948).

  2. 2

    Hall, D. A., Biochem. J., 41, 299 (1947).

  3. 3

    Hall, D. A., Biochem. J., 42, ix (1948).

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    Edlbacher, S., and von Bidder, H., Z. physiol. Chem., 273, 163 (1943).

  5. 5

    Walker, A. C., and Schmidt, C. L. A., Arch. Biochem., 5, 450 (1944).

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HALL, D. A Natural Precursor of the Folic Acid Complex. Nature 162, 178–179 (1948) doi:10.1038/162178b0

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