Synthesis of Vomipyrine

Article metrics


AN outstanding result of Wieland‘s long series of investigations of vomicine was the degradation of the alkaloid to a base, C15H16N2, termed vomipyrine1. This afforded yellow salts, and the spectrochemical behaviour clearly indicated its constitution as an alkylated pyrroquinoline, C11H7N2.C4H9, although the position of fusion of the rings and the position and distribution of the alkyl group or groups (2Et, Me, Pr, Bu, etc.) was unknown. Guesses based on the earlier strychnine formulæ were disproved by synthesis2.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Wieland, H., and Horner, L., Annalen, 528, 73 (1937).

  2. 2

    Horner, L., Annalen, 540, 73 (1939); cf. ref. 9.

  3. 3

    Robinson, R., Experientia, 2, 28 (1946). Openshaw, H. T., and Robinson, R., Nature, 157, 438 (1946). Chakravarti, R. N., and Robinson, R., Nature, 160, 18 (1947).

  4. 4

    Pausacker, K. H., and Robinson, R., J. Chem. Soc. (in the press, 1948).

  5. 5

    Perkin, W. H., Robinson, R., and Smith, J. C., J. Chem. Soc., 1239 (1932).

  6. 6

    Bailey, A. S., and Robinson, R., Nature, 161, 433 (1948).

  7. 7

    Bradford, L., Elliott, T. J., and Rowe, F. M., J. Chem. Soc., 437 (1947).

  8. 8

    Kyker, G. C., and Bost, R. W., J. Amer. Chem. Soc., 61, 2469 (1939).

  9. 9

    Wieland, H., and Horner, L., Annalen, 536, 89 (1938); cf. ref. 2.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

ROBINSON, R., STEPHEN, A. Synthesis of Vomipyrine. Nature 162, 177–178 (1948) doi:10.1038/162177a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.