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Synthesis of Vomipyrine

Nature volume 162, pages 177178 (31 July 1948) | Download Citation

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Abstract

AN outstanding result of Wieland‘s long series of investigations of vomicine was the degradation of the alkaloid to a base, C15H16N2, termed vomipyrine1. This afforded yellow salts, and the spectrochemical behaviour clearly indicated its constitution as an alkylated pyrroquinoline, C11H7N2.C4H9, although the position of fusion of the rings and the position and distribution of the alkyl group or groups (2Et, Me, Pr, Bu, etc.) was unknown. Guesses based on the earlier strychnine formulæ were disproved by synthesis2.

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References

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Affiliations

  1. Dyson Perrins Laboratory, University, Oxford. July 7.

    • R. ROBINSON
    •  & A. M. STEPHEN

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https://doi.org/10.1038/162177a0

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