Influence of Hydrogen Ions and Neutral Salts upon the Hydration of Interstitial Connective Tissue

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Abstract

WHEN a piece of interstitial connective tissue covering the thigh muscles of a rat was placed in water adjusted to pH. 4·5, within a few hours it became opaque, white and shrunken. On the other hand, a piece treated at pH. 11·0 became translucent, grey and swollen. These changes were mutually reversible and could be repeated several times. Observations with the dark-ground microscope showed that this swelling was not due to any change in the collagen fibrils but to a widening of the spaces between them ; shrinkage Was accompanied by an obliteration of such spaces and by a condensation and crimping of the collagen bundles.

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DAY, T. Influence of Hydrogen Ions and Neutral Salts upon the Hydration of Interstitial Connective Tissue. Nature 162, 152–153 (1948) doi:10.1038/162152b0

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