Letter | Published:

Influence of Hydrogen Ions and Neutral Salts upon the Hydration of Interstitial Connective Tissue

Nature volume 162, pages 152153 (24 July 1948) | Download Citation

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Abstract

WHEN a piece of interstitial connective tissue covering the thigh muscles of a rat was placed in water adjusted to pH. 4·5, within a few hours it became opaque, white and shrunken. On the other hand, a piece treated at pH. 11·0 became translucent, grey and swollen. These changes were mutually reversible and could be repeated several times. Observations with the dark-ground microscope showed that this swelling was not due to any change in the collagen fibrils but to a widening of the spaces between them ; shrinkage Was accompanied by an obliteration of such spaces and by a condensation and crimping of the collagen bundles.

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References

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    , Nature, 159, 100 (1947).

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    , Arch. micr. Anat., 12, 391 (1876).

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    , "Physical Chemistry of Cells and Tissues", 296 (Churchill, London, 1945).

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Affiliations

  1. Department of Pathology, St. Thomas‘s Hospital Medical School, London, S.E.1. March 21.

    • T. D. DAY

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DOI

https://doi.org/10.1038/162152b0

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