Letter | Published:

Metachloridine-substituted Aryl Biguanides as Possible Antimalarial Compounds

Nature volume 162, pages 146147 (24 July 1948) | Download Citation

Subjects

Abstract

METANILAMIDES are reported to have no antibacterial action1, and from the parallel nature of the antimalarial and antibacterial properties of sulphanilamides, discouraged research in the field of metanilamides as possible antimalarials. Recently, English et al.2 discovered enhanced antimalarial activity in 2-sulphanilamido-5-chloropyrimidine, and their work resulted in the discovery of metachloridine3 (SN 11437) (2-metanilamido-5-chloropyrimidine), which has been found to be effective both in avian3 and human malarias4,5,6. Metachloridine is 5-chloropyrimidine-substituted metanilamide, the action of which is not affected by the presence of p-aminobenzoic acid, and is supposed3 to have a double mode of action due to the presence of 5-chloropyrimidine and metanilamide parts in the molecule.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , Chem. Rev., 27, 182 (1940).

  2. 2.

    , , et al., J. Amer. Chem. Soc., 68, 453 (1946).

  3. 3.

    , , et al., J. Amer. Chem. Soc, 68, 1039(1946).

  4. 4.

    , and , J. Parasitol, 32, 340 (1946).

  5. 5.

    , and , J. Parasitol, 32, 325 (1946).

  6. 6.

    , "A Survey of Antimalarial Drugs, 1941–45", 1, 294.

  7. 7.

    , , and , J. Indian Inst. Sci., 29 A, 15 (1947). Cf. Curr. Sci., 16, 252 (1947).

  8. 8.

    , , and , Curr. Sci., 16, 386 (1947).

  9. 9.

    , Monatsh., 48, 147 (1927).

Download references

Author information

Affiliations

  1. Organic Chemistry Laboratories, Indian Institute of Science, Bangalore. Feb. 27

    • H. L. BAMI
    • , B. H. IYER
    •  & P. C. GUHA

Authors

  1. Search for H. L. BAMI in:

  2. Search for B. H. IYER in:

  3. Search for P. C. GUHA in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/162146b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.