Letter | Published:

N-Diethylaminoethylphenothiazine : a Specific Inhibitor of Pseudocholinesterase

Nature volume 162, page 146 (24 July 1948) | Download Citation

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Abstract

Mendel and Rudney1 demonstrated that mammalian tissues may contain two distinct esterases, both capable of hydrolysing acetylcholine in vitro : a specific enzyme (‘true' cholinesterase) and a nonspecific enzyme (‘pseudo' cholinesterase). The chemically dissimilar natures of the two enzymes were indicated by their selective behaviour towards particular choline esters2 and by the selective toxic effects, on the pseudo esterase, of the dimethylcarbamate of (2-hydroxy : 5-phenylbenzyl)-trimethylammonium bromide3 and of diisopropylfluorophosphate4. Both these substances exert powerful effects on pseudocholinesterase at concentrations which are relatively ineffective against true cholinesterase.

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References

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Author information

Author notes

    • J. J. GORDON

    Present address: Research Department, Britstol Mental Hospital, Fishponds, Bristol.

Affiliations

  1. Biological Division, May and Baker, Ltd., Dagenham, Essex. March 19. and Research Department, Bristol Mental Hospital, Fishponds, Bristol.

    • J. J. GORDON

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DOI

https://doi.org/10.1038/162146a0

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