Hæmophilia in Dogs

    Article metrics

    Abstract

    F. B. Hutt, C. G. Rickard and R. A. Field (J. Hered., 39, 3 ; 1948) describe the discovery of a sex-linked hæmophilia in dogs. This shows as a lameness and by swellings in various parts of the body when the puppy is six weeks old. Examination showed that the lameness was due to hæmorrhage at the joints. Of seventeen puppies which have been recognized as hemophilics, not one has been raised to maturity. Several tests for hæmophilia in man Were applied to these dogs and were found to give positive results. The breeding histories of the parents of the puppies were known ; as a result, it was easily seen that the condition was due to a sex-linked recessive gene called h. The importance of the discovery lies in the fact that the comparative physiology of dog and man is well known, and the condition will be of value in research. It is noteworthy that this case in dogs is one of the few sex-linked genes in mammals other than man where seven or eight sex-linked characters are known. The pig has an inherited hæmophilia ; but this is controlled by a recessive gene on an autosome. It is probable that paralytic or lame puppies which were destroyed in the past were in reality sometimes hæmophilic. It would be desirable to discover whether any hæmophilic puppies survive to maturity ; on the different genetic backgrounds of different breeds, the recessive gene may not always have a lethal effect.

    Access options

    Rent or Buy article

    Get time limited or full article access on ReadCube.

    from$8.99

    All prices are NET prices.

    Rights and permissions

    Reprints and Permissions

    About this article

    Cite this article

    Hæmophilia in Dogs. Nature 162, 136 (1948) doi:10.1038/162136b0

    Download citation

    Comments

    By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.