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Pathogenicity of Aspergillus nidulans

Nature volume 162, page 98 (17 July 1948) | Download Citation



THERE are numerous reports in medical literature of infection of man and other animals by species of the fungal genus Aspergillus. Pathogenicity of A. fumigatus is comparatively well known, and A. nidulans has occurred in circumstances which seemed to implicate it as a cause of disease. Dr. Charles H. Drake has studied the latter species in a recent paper (Mycopathologia, 4, Fasc. 2, pp. 103 ; 1948). He finds that the fungus is pathogenic to rabbits, causing initially a purulent inflammation with abscess formation. Subsequent injections may give rise directly to tubercles, in which the fungus changes morphologically to give actinomycetoid granules. Cell-sap of A. nidulans is not toxic to rabbits, but stimulates the formation of precipitins. This species does not appear to be pathogenic to guinea pigs, which fact might explain some earlier uncertainty about its disease-producing character.

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