Synthetic Analgesics

Article metrics

Abstract

ATTEMPTS to prepare new analgesics have, for many years, been based almost exclusively on the morphine molecule, the peripheral groups of which may be modified considerably with relatively little effect on the biological activity. The synthetic drug ‘Pethidine' (ethyl 4-phenyl-1-methylpiperidine-4-carboxylate) has several structural features in common with morphine, and there is a considerable body of evidence which relates analgesics of the piperidine type to the morphine model1–4. The recently discovered ‘Amidone' (dl-2-dimethylamino-4 : 4-di-phenylheptan-5-one) is also a potent analgesic. We have examined three types of compound for analgesic, antispasmodic and local anæsthetic action. Although none of these compounds is closely related to morphine, several have an analgesic potency equivalent to or approaching that of ‘Pethidine'.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Schaumann, O., Arch. Exp. Path. Pharm., 196, 109 (1940).

  2. 2

    Jensen, K. A., and Lundquist, F., Dansk. Tidsskr. Farm., 17, 173 (1944).

  3. 3

    MacDonald, A. K., Woolfe, G., Bergel, F., Morrison, A. L., and Rinderknecht, H., Brit. J. Pharmacol, 1, 4 (1946).

  4. 4

    Foster, R. H. K., and Carman, A. J., J. Pharm. Exp. Ther., 91, 195 (1947).

  5. 5

    Barr, W., and Cook, J. W., J. Chem. Soc., 438 (1945).

  6. 6

    Badger, G. M., Cook, J. W., and Walker, T., J. Chem. Soc. (in the press).

  7. 7

    Badger, G. M., Cook, J. W., and Crosbie, G. W., J. Chem. Soc., 1432 (1947).

  8. 8

    Davies, O. L., Raventos, J., and Walpole, A. L., Brit. J. Pharmacol., 1, 255 (1946).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

BADGER, G., COOK, J., DONALD, G. et al. Synthetic Analgesics. Nature 162, 21 (1948) doi:10.1038/162021a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.