Abstract
IN a previous communication in Nature1, the inhibitory effect of soluble diploicin derivatives on the growth of the tubercle bacillus in vitro was described, and it was suggested that simpler diphenyl ether derivatives might also exhibit antitubercular properties. We have now prepared a variety of diphenyl ether derivatives as well as some related compounds in which the oxygen link has been replaced by — O(CH2)n—, >CO, etc. Several of these comparatively simple compounds are much more active than derivatives of diploicin. This activity against Mycobacteria is also shared by diphenylene oxide derivatives.
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References
Barry, Nature, 158, 131 (1946).
Walter, "Festschrift Emil C. Barrell", Basel, 266–283 (1936).
Goris and Sabetay, C.R. Acad. Sci., Paris, 223, 933 (1946).
Marshak, U.S. Public Health Reports, 62, 3 (1947).
Note added in proof. In a recent paper by Stoll, Brack and Renz (Experientia, 3 (3), 115; (1947)), similar results are recorded with usnic acid.
Curd and Robertson, J. Chem. Soc., 898 (1937).
Cullinane and Padfield, J. Chem. Soc., 1131 (1935).
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BARRY, V., O'ROURKE, L. & TWOMEY, D. Antitubercular Activity of Diphenyl Ethers and Related Compounds. Nature 160, 800–801 (1947). https://doi.org/10.1038/160800a0
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DOI: https://doi.org/10.1038/160800a0
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