Letter | Published:

Methionine in Urine

Nature volume 160, pages 604605 (01 November 1947) | Download Citation

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Abstract

In 1944 Albanese, Frankston and Irby1 published their hydrogen peroxide – perchloric acid oxidation method for the estimation of methionine in protein hydrolysates and human urine. They stated: “… the applicability of the procedure to the urine was established by means of a study which demonstrated that the normal urinary constituents failed to react as methionine. This practice was further justified by the observations that the ingestion of dl-methionine by normal individuals resulted in a prompt elevation of the methionine level in the urine, as determined by our method. From a limited series of observations, it has been found that the normal adult (male) on a normal diet excretes 247 to 494 mgm. of methionine daily.”

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References

  1. 1.

    , and , J. Biol. Chem., 156, 293 (1944).

  2. 2.

    , âœClinical Biochemistryâ (Philadelphia, Pa., 1940).

  3. 3.

    , Lancet, 637 (Nov. 2, 1946).

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Affiliations

  1. The British Drug Houses, Ltd., London, N.1. July 8.

    • EDWARD G. TOMICH

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DOI

https://doi.org/10.1038/160604a0

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