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Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients

Abstract

Objective:

Evaluate the efficacy of protein hydrolysate co-ingestion as a dietary strategy to improve blood glucose homeostasis under free-living conditions in long-standing type 2 diabetes patients.

Methods:

A total of 13 type 2 diabetes patients were enrolled in a randomized, double-blind cross-over design and studied on two occasions for 40 h under strict dietary standardization but otherwise normal, free-living conditions. In one trial, subjects ingested a protein hydrolysate (0.4 g kg−1 bw casein hydrolysate, PRO) with every main meal. In the other trial, a placebo was ingested (PLA). Blood glucose concentrations were assessed by continuous glucose monitoring.

Results:

Average 24 h glucose concentrations were similar between the PLA and the PRO trials (8.9±0.8 vs 9.2±0.7 mmol l−1, respectively). Hyperglycemia (glucose concentrations >10 mmol l−1) was experienced 34±9% of the time (8±2 h per 24 h) in the PLA trial. Protein hydrolysate co-ingestion with each main meal (PRO) did not reduce the prevalence of hyperglycemia (39±10%, 9±2 h per 24 h; P=0.2).

Conclusion:

Co-ingestion of a protein hydrolysate with each main meal does not improve glucose homeostasis over a 24 h period in long-standing type 2 diabetes patients.

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Acknowledgements

We thank A Menarini Diagnostics BENELUX and Hanneke van Milligen for technical assistance and the subjects who volunteered to participate in these trials for their enthusiastic support. This study was supported by a grant from DSM Food Specialties (Delft, The Netherlands)

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Correspondence to R J F Manders.

Additional information

Contributors: RJFM, SFEP, WHMS and LJCvL designed the study. RJFM and MHV organized and carried out the clinical trials. RJFM performed all calculations and the statistical analyses. All authors contributed to the final version of the manuscript.

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Manders, R., Praet, S., Vikström, M. et al. Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients. Eur J Clin Nutr 63, 121–126 (2009). https://doi.org/10.1038/sj.ejcn.1602891

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