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Effects of a short-term intervention with a paleolithic diet in healthy volunteers



Prevention of cardiovascular diseases by paleolithic or hunterer-gatherer diets has been discussed during recent years.


Our aim was to assess the effect of a paleolithic diet in a pilot study on healthy volunteers during 3 weeks. The intention was to include 20 subjects, of whom 14 fulfilled the study. Complete dietary assessment was available for six subjects.


Mean weight decreased by 2.3 kg (P<0.001), body mass index by 0.8 (P<0.001), waist circumference by 0.5 cm (P=0.001), systolic blood pressure by 3 mm Hg (P=0.03) and plasminogen activator inhibitor-1 by 72% (P=0.020). Regarding nutrient intake, intake of energy decreased by 36%, and other effects were also observed, both favourable (fat composition, antioxidants, potassium-sodium rate) and unfavourable (calcium).


This short-term intervention showed some favourable effects by the diet, but further studies, including control group, are needed.

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plasminogen activator inhibitor-1


Homeostatic model assessment


C-reactive protein


  • Ayoob KT, Duyff RL, Quagliani D (2002). Position of the American Dietetic Association: food and nutrition misinformation. J Am Diet Assoc 102, 260–266.

    Article  Google Scholar 

  • Cordain L, Eaton SB, Miller JB, Mann N, Hill K (2002). The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic. Eur J Clin Nutr 56 (Suppl 1), S42–S52.

    Article  Google Scholar 

  • Cordain L, Miller JB, Eaton SB, Mann N, Holt SH, Speth JD (2000). Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets. Am J Clin Nutr 71, 682–692.

    Article  CAS  Google Scholar 

  • Eaton SB, Cordain L, Lindeberg S (2002). Evolutionary health promotion: a consideration of common counter arguments. Prev Med 34, 119–123.

    Article  Google Scholar 

  • Enghardt Barbieri H, Lindvall C (2005). Swedish Nutrition Recommendations Objectified (SNO) – Basis for General Advice on Food Consumption for Healthy Adults (no. 20). National Food Administration: Uppsala, Sweden.

    Google Scholar 

  • Jonsson T, Ahren B, Pacini G, Sundler F, Wierup N, Steen S et al. (2006). A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs. Nutr Metab (London) 3, 39.

    Article  Google Scholar 

  • Meneton P, Jeunemaitre X, de Wardener HE, MacGregor GA (2005). Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases. Physiol Rev 85, 679–715.

    Article  CAS  Google Scholar 

  • O'Dea K (1984). Marked improvement in carbohydrate and lipid metabolism in diabetic Australian aborigines after temporary reversion to traditional lifestyle. Diabetes 33, 596–603.

    Article  CAS  Google Scholar 

  • O'Keefe Jr JH, Cordain L (2004). Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer. Mayo Clin Proc 79, 101–108.

    Article  Google Scholar 

  • Suter PM, Sierro C, Vetter W (2002). Nutritional factors in the control of blood pressure and hypertension. Nutr Clin Care 5, 9–19.

    Article  Google Scholar 

  • Villareal DT, Fontana L, Weiss EP, Racette SB, Steger-May K, Schechtman KB et al. (2006). Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch Intern Med 166, 2502–2510.

    Article  Google Scholar 

  • Wallace TM, Matthews DR (2002). The assessment of insulin resistance in man. Diabet Med 19, 527–534.

    Article  CAS  Google Scholar 

  • Wallace TM, Levy JC, Matthews DR (2004). Use and abuse of HOMA modeling. Diabet Care 27, 1487–1495.

    Article  Google Scholar 

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This study was supported by grants from Stockholm County Council. We thank dietitian Viveca Annell who prepared the diet compendium on paleolithic diet, and participated in the seminars. We also thank research nurse Kirsti Westerlund, who planned and performed the medical testing.

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Correspondence to P E Wändell.

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Österdahl, M., Kocturk, T., Koochek, A. et al. Effects of a short-term intervention with a paleolithic diet in healthy volunteers. Eur J Clin Nutr 62, 682–685 (2008).

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