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Methodology for studying postprandial lipid metabolism

European Journal of Clinical Nutrition volume 61, pages 1145–1161 (2007)Cite this article

A Corrigendum to this article was published on 03 September 2008

Abstract

Background:

Postprandial lipid metabolism in humans has deserved much attention during the last two decades. Although fasting lipid and lipoprotein parameters reflect body homeostasis to some extent, the transient lipid and lipoprotein accumulation that occurs in the circulation after a fat-containing meal highlights the individual capacity to handle an acute fat input. An exacerbated postprandial accumulation of triglyceride-rich lipoproteins in the circulation has been associated with an increased cardiovascular risk.

Methods:

The important number of studies published in this field raises the question of the methodology used for such postprandial studies, as reviewed.

Results:

Based on our experiences, the present review reports and discuss the numerous methodological issues involved to serve as a basis for further works. These aspects include aims of the postprandial tests, size and nutrient composition of the test meals and background diets, pre-test conditions, characteristics of subjects involved, timing of sampling, suitable markers of postprandial lipid metabolism and calculations.

Conclusion:

In conclusion, we stress the need for standardization of postprandial tests.

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Acknowledgements

This work was commissioned by the Nutritional Value of Food Task Force of the European branch of the International Life Sciences Institute (ILSI Europe). Industry members of this task force are Nestlé, Danone, Südzucker and Danisco. For further information about ILSI Europe, email info@ilsieurope.be or call +32 27710014. The opinions expressed in this article are those of the authors and do not necessarily represent the views of ILSI Europe.

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Authors and Affiliations

  1. INSERM, 476 ‘Nutrition Humaine et lipides’, Marseille, France

    D Lairon

  2. INRA, 1260, Marseille, France

    D Lairon

  3. Univ Méditerranée Aix-Marseille 2, Faculté de Médecine, IPHM-IFR 125, Marseille, France

    D Lairon

  4. Department of Medicine, Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofía, University of Cordoba, Córdoba, Spain

    J Lopez-Miranda

  5. Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights Reading (Berks.), UK

    C Williams

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  1. D Lairon
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  2. J Lopez-Miranda
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  3. C Williams
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Correspondence to D Lairon.

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Lairon, D., Lopez-Miranda, J. & Williams, C. Methodology for studying postprandial lipid metabolism. Eur J Clin Nutr 61, 1145–1161 (2007). https://doi.org/10.1038/sj.ejcn.1602749

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602749

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