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Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial



To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients.


Placebo-controlled, crossover, randomized trial.


Cardiology Department of Hospital del Mar and Institut Municipal d’Investigació Mèdica (Barcelona).


Twenty-eight stable coronary heart disease patients.


A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used.


Interleukin-6 (P<0.002) and C-reactive protein (P=0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile.


Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.

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  • Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q et al. (2005). Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 437, 45–46.

    CAS  Article  Google Scholar 

  • Berliner JA, Territo MC, Sevanian A, Kim JA, Bamshad B, Esterson M et al. (1990). Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest 85, 1260–1266.

    CAS  Article  Google Scholar 

  • Bogani P, Galli C, Villa M, Visioli F (2007). Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis 190, 181–186.

    CAS  Article  Google Scholar 

  • Carluccio MA, Siculella L, Ancora MA, Massaro M, Scoditti E, Storelli C et al. (2003). Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol 23, 622–629.

    CAS  Article  Google Scholar 

  • Covas MI, Nyyssönen K, Poulsen HE, Kaikkonen J, Zunft HJF, Kiesewetter H et al. (2006a). The effect of polyphenols in olive oil on heart disease risk factors. Ann Int Med 145, 333–341.

    CAS  Article  Google Scholar 

  • Covas MI, Ruiz-Gutiérrez V, de la Torre R, Kafatos A, Lamuela-Raventós R, Osada J et al. (2006b). Olive oil minor components: evidence to date of health benefits in humans. Nutr Rev 64 (Supplement 1), 20–30.

    Article  Google Scholar 

  • Elosua R, Marrugat J, Molina L, Pons S, Pujol E (1994). Validation of the minnesota leisure time physical activity questionnaire in spanish men. The MARATHOM Investigators. Am J Epidemiol 139, 1197–1209.

    CAS  Article  Google Scholar 

  • Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G et al. (2004). Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 292, 1440–1446.

    CAS  Article  Google Scholar 

  • Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Ruiz-Gutiérrez V, Covas MI et al. (2006). Effects of a mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Int Med 145, 1–11.

    Article  Google Scholar 

  • Fito M, Cladellas M, de la TR, Marti J, Alcantara M, Pujadas-Bastardes M et al. (2005). Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial. Atherosclerosis 181, 149–158.

    CAS  Article  Google Scholar 

  • Helsing E (1995). Traditional diets and disease patterns of the Mediterranean, circa 1960. Am J Clin Nutr 61, 1329S–1337S.

    CAS  Article  Google Scholar 

  • Kim JA, Territo MC, Wayner E, Carlos TM, Parhami F, Smith CW et al. (1994). Partial characterization of leukocyte binding molecules on endothelial cells induced by minimally oxidized LDL. Arterioscler Thromb 14, 427–433.

    Article  Google Scholar 

  • Kris-Etherton PM (1999). Monounsaturated fatty acids and risk of cardiovascular disease. Circulation 100, 1253–1258.

    CAS  Article  Google Scholar 

  • Leger CL, Carbonneau MA, Michel F, Mas E, Monnier L, Cristol JP et al. (2005). A thromboxane effect of a hydroxytyrosol-rich olive oil wastewater extract in patients with uncomplicated type I diabetes. Eur J Clin Nutr 59, 727–730.

    CAS  Article  Google Scholar 

  • Miró-Casas E, Covas MI, Fitó M, Farré-Albadalejo M, Marrugat J, de la Torre R (2003). Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans. Eur J Clin Nutr 57, 186–190.

    Article  Google Scholar 

  • Murase T, Kume N, Hase T, Shibuya Y, Nishizawa Y, Tokimitsu I et al. (1999). Gallates inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of leukocyte adhesion molecules in vascular endothelial cells. Arterioscler Thromb Vasc Biol 19, 1412–1420.

    CAS  Article  Google Scholar 

  • Perona JS, Cabello-Moruno R, Ruiz-Gutierrez V (2006). The role of virgin olive oil components in the modulation of endothelial function. J Nutr Biochem 17, 429–445.

    CAS  Article  Google Scholar 

  • Ross R (1999). Atherosclerosis – an inflammatory disease. N Engl J Med 340, 115–126.

    CAS  Article  Google Scholar 

  • Schroder H, Covas MI, Marrugat J, Vila J, Pena A, Alcantara M et al. (2001). Use of a three-day estimated food record, a 72-h recall and a food- frequency questionnaire for dietary assessment in a Mediterranean Spanish population. Clin Nutr 20, 429–437.

    CAS  Article  Google Scholar 

  • Tsimikas S, Philis-Tsimikas A, Alexopoulos S, Sigari F, Lee C, Reaven PD (1999). LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress. Arterioscler, Thromb Vasc Biol 19, 122–130.

    CAS  Article  Google Scholar 

  • Tunstall-Pedoe H, Kuulasmaa K, Mahonen M, Tolonen H, Ruokokoski E, Amouyel P (1999). Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. Lancet 353, 1547–1557.

    CAS  Article  Google Scholar 

  • Tzoulaki I, Murray GD, Lee AJ, Rumley A, Lowe GD, Fowkes FG (2005). C-reactive protein, interleukin-6, and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population: Edinburgh Artery Study. Circulation 112, 976–983.

    CAS  Article  Google Scholar 

  • Visioli F, Caruso D, Grande S, Bosisio R, Villa M, Galli G et al. (2005). Virgin Olive Oil Study (VOLOS): vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patients. Eur J Nutr 44, 121–127.

    CAS  Article  Google Scholar 

  • Weinbrenner T, Cladellas M, Isabel CM, Fito M, Tomas M, Senti M et al. (2003). High oxidative stress in patients with stable coronary heart disease. Atherosclerosis 168, 99–106.

    CAS  Article  Google Scholar 

  • Wu D, Koga T, Martin KR, Meydani M (1999). Effect of vitamin E on human aortic endothelial cell production of chemokines and adhesion to monocytes. Atherosclerosis 147, 297–307.

    CAS  Article  Google Scholar 

  • Yaqoob P, Knapper JA, Webb DH, Williams CM, Newsholme EA, Calder PC (1998). Effect of olive oil on immune function in middle-aged men. Am J Clin Nutr 67, 129–135.

    CAS  Article  Google Scholar 

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We thank the Ferderació Cooperatives Agràries de Catalunya for provide the olive oil used in the study. Fondo de investigación Sanitaria:FIS-PI02-0791 and partially supported by CIBER: CB-03-0028.

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Correspondence to M Fitó.

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Guarantor: M Fitó.

SOLOS (Spanish Olive Oil Study) Study Investigators: Alcántara M, Covas MI, Fitó M, Marrugat J, Schröder H, Weinbrenner T, Alcántara M, Muñoz D, Guxens M (Unitat de Lipids i Epidemiologia Cardiovascular, Institut Muncipal d’Investigació Mèdica), de la Torre R, Farré M, Menoyo E, Pujadas-Bastardes M, Closas N, Khymenets O (Unitat de Farmacologia, Institut Muncipal d’Investigació Mèdica), and de la Torre-Boronat C, Gimeno E, Lamuela R and López MC (Departament de Bromatologia i Nutricio, Facultat de Farmacia, Universitat de Barcelona).

Contributors: Drs MF, MC, and MIC had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of analyses; Study concept and design: MF, MC, MIC, RT, JM; Acquisition of the data: MA, DM, MF, MC, MP-B, JM, HS; Analysis and interpretation of data: MF, MC, MIC, RT, MCL-S, JM; Drafting of the manuscript: MF, MC, MIC; Critical revision of the manuscript for important intellectual content: MA, MC, MIC, MF, RT, HS, JM, JM, MCL-S, JB, DM, MP-B; Statistical analyses: MF, MC; Obtained funding: MC, MIC, JB; Administrative, technical and material support: MF, JM, DM, MP-B, HS, MA.

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Fitó, M., Cladellas, M., de la Torre, R. et al. Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial. Eur J Clin Nutr 62, 570–574 (2008).

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  • olive oil
  • phenolic compounds
  • inflammation
  • interleukins
  • coronary heart disease

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