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Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial



To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients.


Placebo-controlled, crossover, randomized trial.


Cardiology Department of Hospital del Mar and Institut Municipal d’Investigació Mèdica (Barcelona).


Twenty-eight stable coronary heart disease patients.


A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used.


Interleukin-6 (P<0.002) and C-reactive protein (P=0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile.


Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.

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We thank the Ferderació Cooperatives Agràries de Catalunya for provide the olive oil used in the study. Fondo de investigación Sanitaria:FIS-PI02-0791 and partially supported by CIBER: CB-03-0028.

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Correspondence to M Fitó.

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Guarantor: M Fitó.

SOLOS (Spanish Olive Oil Study) Study Investigators: Alcántara M, Covas MI, Fitó M, Marrugat J, Schröder H, Weinbrenner T, Alcántara M, Muñoz D, Guxens M (Unitat de Lipids i Epidemiologia Cardiovascular, Institut Muncipal d’Investigació Mèdica), de la Torre R, Farré M, Menoyo E, Pujadas-Bastardes M, Closas N, Khymenets O (Unitat de Farmacologia, Institut Muncipal d’Investigació Mèdica), and de la Torre-Boronat C, Gimeno E, Lamuela R and López MC (Departament de Bromatologia i Nutricio, Facultat de Farmacia, Universitat de Barcelona).

Contributors: Drs MF, MC, and MIC had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of analyses; Study concept and design: MF, MC, MIC, RT, JM; Acquisition of the data: MA, DM, MF, MC, MP-B, JM, HS; Analysis and interpretation of data: MF, MC, MIC, RT, MCL-S, JM; Drafting of the manuscript: MF, MC, MIC; Critical revision of the manuscript for important intellectual content: MA, MC, MIC, MF, RT, HS, JM, JM, MCL-S, JB, DM, MP-B; Statistical analyses: MF, MC; Obtained funding: MC, MIC, JB; Administrative, technical and material support: MF, JM, DM, MP-B, HS, MA.

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Fitó, M., Cladellas, M., de la Torre, R. et al. Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial. Eur J Clin Nutr 62, 570–574 (2008).

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