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  • Original Article
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Carotid artery compliance in users of plant stanol ester margarine

European Journal of Clinical Nutrition volume 62, pages 218–224 (2008)Cite this article

Abstract

Objective:

To investigate the effects of stanol ester margarine use in healthy subjects on arterial compliance, endothelial function and intima-media thickness.

Design:

Case–control study comparing regular stanol ester margarine users to non-users.

Setting:

Occupational health service clinic.

Subjects:

We recruited 50 cases and 50 controls (mean age 51±8, range 26–65 years). All subjects were non-smokers and the study groups were matched for age and sex. As cases, we invited subjects who had been using regularly (daily) plant stanol ester margarine for a period of 2 years or longer. Non-invasive ultrasound was used to measure carotid artery compliance, carotid intima-media thickness and brachial artery flow-mediated endothelial dependent vasodilatation.

Results:

The carotid artery compliance was non-significantly higher in cases compared with controls, 1.84±1.02 vs 1.58±0.76 %/10 mm Hg (P=0.13). The difference in compliance became statistically significant (P=0.04) when the unbalance between the groups in family history of coronary artery disease and years of education were taken into account. There was also a significant dose–response relationship between stanol margarine use and carotid compliance, longer use being associated with higher compliance. Serum lipoproteins, blood pressure, flow-mediated dilation and intima-media thickness values did not differ between cases and controls.

Conclusion:

These data raise the possibility that regular stanol ester margarine use may be associated with beneficial changes in arterial compliance. Intervention studies are needed to test this hypothesis and to reveal possible mechanisms.

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References

  • Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D et al. (1995). Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 26, 1235–1241.

    Article  CAS  PubMed  Google Scholar 

  • Arnett DK, Chambless LE, Kim H, Evans GW, Riley W (1999). Variability in ultrasonic measurements of arterial stiffness in the Atherosclerosis Risk in Communities Study. Ultrasound Med Biol 25, 175–180.

    Article  CAS  PubMed  Google Scholar 

  • Arstila M, Impivaara O, Maki J (1990). New ergometric reference values for clinical exercise tests. Scand J Clin Lab Invest 50, 747–755.

    Article  CAS  PubMed  Google Scholar 

  • Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME, London GM (1998). Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 32, 570–574.

    Article  CAS  PubMed  Google Scholar 

  • Borow KM, Newburger JW (1982). Noninvasive estimation of central aortic pressure using the oscillometric method for analyzing systemic artery pulsatile blood flow: comparative study of indirect systolic, diastolic, and mean brachial artery pressure with simultaneous direct ascending aortic pressure measurements. Am Heart J 103, 879–886.

    Article  CAS  PubMed  Google Scholar 

  • Bots ML, Hoes AW, Hofman A, Witteman JC, Grobbee DE (1999). Cross-sectionally assessed carotid intima-media thickness relates to long-term risk of stroke, coronary heart disease and death as estimated by available risk functions. J Intern Med 245, 269–276.

    Article  CAS  PubMed  Google Scholar 

  • Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID et al. (1992). Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340, 1111–1115.

    Article  CAS  PubMed  Google Scholar 

  • Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR et al. (1997). Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 146, 483–494.

    Article  CAS  PubMed  Google Scholar 

  • Chan SY, Mancini GB, Kuramoto L, Schulzer M, Frohlich J, Ignaszewski A (2003). The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. J Am Coll Cardiol 42, 1037–1043.

    Article  CAS  PubMed  Google Scholar 

  • Expert Panel (1996). Prevention of coronary heart disease in clinical practice in Finland (in Finnish). Finnish Med J 51, 783–802.

    Google Scholar 

  • Expert Panel (2004). Treatment of dyslipidemias (in Finnish). Duodecim 120, 1794–1816.

    Google Scholar 

  • Ferrier KE, Muhlmann MH, Baguet JP, Cameron JD, Jennings GL, Dart AM et al. (2002). Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension. J Am Coll Cardiol 39, 1020–1025.

    Article  CAS  PubMed  Google Scholar 

  • Friedewald WT, Levy RI, Fredrickson DS (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499–502.

    CAS  PubMed  Google Scholar 

  • Gokce N, Keaney Jr JF, Hunter LM, Watkins MT, Nedeljkovic ZS, Menzoian JO et al. (2003). Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol 41, 1769–1775.

    Article  PubMed  Google Scholar 

  • Haapanen A, Koskenvuo M, Kaprio J, Kesaniemi YA, Heikkila K (1989). Carotid arteriosclerosis in identical twins discordant for cigarette smoking. Circulation 80, 10–16.

    Article  CAS  PubMed  Google Scholar 

  • Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, Liu CH et al. (1998). The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 128, 262–269.

    Article  CAS  PubMed  Google Scholar 

  • Juonala M, Viikari JS, Laitinen T, Marniemi J, Helenius H, Rönnemaa T et al. (2004). Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study. Circulation 110, 2918–2923.

    Article  PubMed  Google Scholar 

  • Juonala M, Järvisalo MJ, Mäki-Torkko N, Kähönen M, Viikari JSA, Raitakari OT (2005). Risk factors identified in childhood and decreased carotid artery elasticity in adulthood. The Cardiovascular Risk in Young Finns Study. Circulation 112, 1486–1493.

    Article  PubMed  Google Scholar 

  • Järvisalo MJ, Rönnemaa T, Volanen I, Kaitosaari T, Kallio K, Hartiala JJ et al. (2002). Brachial artery dilatation responses in healthy children and adolescents. Am J Physiol Heart Circ Physiol 282, H87–H92.

    Article  PubMed  Google Scholar 

  • Karamanoglu M, O'Rourke MF, Avolio AP, Kelly RP (1993). An analysis of the relationship between central aortic and peripheral upper limb pressure waves in man. Eur Heart J 14, 160–167.

    Article  CAS  PubMed  Google Scholar 

  • Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R (2003). Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 78, 965–978.

    Article  CAS  PubMed  Google Scholar 

  • Law M (2000). Plant sterol and stanol margarines and health. BMJ 320, 861–864.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Luoto R, Simojoki M, Uutela A, Boice Jr JD, McLaughlin JK, Puska P (2004). Consistency of use of plant stanol ester margarine in Finland. Public Health Nutr 7, 63–68.

    PubMed  Google Scholar 

  • McVeigh GE, Brennan GM, Cohn JN, Finkelstein SM, Hayes RJ, Johnston GD (1994). Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. Arterioscler Thromb 14, 1425–1429.

    Article  CAS  PubMed  Google Scholar 

  • Miettinen TA, Gylling H (2004). Plant stanol and sterol esters in prevention of cardiovascular diseases. Ann Med 36, 126–134.

    Article  CAS  PubMed  Google Scholar 

  • Miettinen TA, Puska P, Gylling H, Vanhanen H, Vartiainen E (1995). Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 333, 1308–1312.

    Article  CAS  PubMed  Google Scholar 

  • Mullen MJ, Kharbanda RK, Cross J, Donald AE, Taylor M, Vallance P et al. (2001). Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia. Circ Res 88, 145–151.

    Article  CAS  PubMed  Google Scholar 

  • Nestel PJ, Pomeroy SE, Sasahara T, Yamashita T, Liang YL, Dart AM et al. (1997). Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability. Arterioscler Thromb Vasc Biol 17, 1163–1170.

    Article  CAS  PubMed  Google Scholar 

  • Nestel P, Shige H, Pomeroy S, Cehun M, Abbey M, Raederstorff D (2002). The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr 76, 326–330.

    Article  CAS  PubMed  Google Scholar 

  • O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson Jr SK (1999). Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340, 14–22.

    Article  CAS  PubMed  Google Scholar 

  • Poli A, Tremoli E, Colombo A, Sirtori M, Pignoli P, Paoletti R (1988). Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients. A new model for the quantitation and follow-up of preclinical atherosclerosis in living human subjects. Atherosclerosis 70, 253–261.

    Article  CAS  PubMed  Google Scholar 

  • Raitakari OT, Porkka KV, Taimela S, Telama R, Rasanen L, Viikari JS (1994). Effects of persistent physical activity and inactivity on coronary risk factors in children and young adults. The Cardiovascular Risk in Young Finns Study. Am J Epidemiol 140, 195–205.

    Article  CAS  PubMed  Google Scholar 

  • Raitakari OT, Juonala M, Kahonen M, Taittonen L, Laitinen T, Maki-Torkko N et al. (2003). Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood–The Cardiovascular Risk in Young Finns Study. JAMA 290, 2277–2283.

    Article  CAS  PubMed  Google Scholar 

  • Salonen JT, Salonen R (1991). Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb 11, 1245–1249.

    Article  CAS  PubMed  Google Scholar 

  • Smilde TJ, van den Berkmortel FW, Wollersheim H, van Langen H, Kastelein JJ, Stalenhoef AF (2000). The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia. Eur J Clin Invest 30, 473–480.

    Article  CAS  PubMed  Google Scholar 

  • Tammi A, Ronnemaa T, Gylling H, Rask-Nissila L, Viikari J, Tuominen J et al. (2000). Plant stanol ester margarine lowers serum total and low-density lipoprotein cholesterol concentrations of healthy children: the STRIP project. Special Turku Coronary Risk Factors Intervention Project. J Pediatr 136, 503–510.

    Article  CAS  PubMed  Google Scholar 

  • Third Report of the National Cholesterol Education Program (NCEP) (2002) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report Circulation 106, 3143–3421.

  • Toikka JO, Laine H, Ahotupa M, Haapanen A, Viikari JS, Hartiala JJ et al. (2000). Increased arterial intima-media thickness and in vivo LDL oxidation in young men with borderline hypertension. Hypertension 36, 929–933.

    Article  CAS  PubMed  Google Scholar 

  • Toikka JO, Niemi P, Ahotupa M, Niinikoski H, Ronnemaa T, Viikari JS et al. (2002). Decreased large artery distensibility in borderline hypertension is related to increased in vivo low-density lipoprotein oxidation. Scand J Clin Lab Invest 62, 301–306.

    Article  CAS  PubMed  Google Scholar 

  • Tomochika Y, Okuda F, Tanaka N, Wasaki Y, Tokisawa I, Aoyagi S et al. (1996). Improvement of atherosclerosis and stiffness of the thoracic descending aorta with cholesterol-lowering therapies in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 16, 955–962.

    Article  CAS  PubMed  Google Scholar 

  • Zieman SJ, Melenovsky V, Kass DA (2005). Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 25, 932–943.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This study was partially supported by Raisio Finland Inc.

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Authors and Affiliations

  1. Department of Clinical Physiology, University of Turku, Turku, Finland

    O T Raitakari

  2. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

    P Salo

  3. Department of Physiology (MCA Research Laboratory), University of Turku, Turku, Finland

    M Ahotupa

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  1. O T Raitakari
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Correspondence to O T Raitakari.

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Raitakari, O., Salo, P. & Ahotupa, M. Carotid artery compliance in users of plant stanol ester margarine. Eur J Clin Nutr 62, 218–224 (2008). https://doi.org/10.1038/sj.ejcn.1602705

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