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Six months of isoflavone supplement increases fat-free mass in obese–sarcopenic postmenopausal women: a randomized double-blind controlled trial

Abstract

Objective:

The aim of this study was to verify if six months of isoflavone supplementation could increase fat-free mass (FFM) and muscle mass index (MMI=appendicular FFM/height2) in obese–sarcopenic postmenopausal women.

Design:

Double-blind randomized study.

Subject:

Eighteen sarcopenic–obese women completed the study (12 on isoflavones and six on placebo). Body composition was measured by dual-energy X-ray absorptiometry. Subjects ingested 70 mg of isoflavones per day (44 mg of diadzein, 16 mg glycitein and 10 mg genestein) or a placebo for 24 weeks.

Results:

The isoflavone group increased significantly appendicular (P=0.034), leg (P=0.016) FFM and MMI (P=0.037), but not the placebo group.

Conclusion:

Six months of isoflavone supplementation increased FFM and MMI in obese–sarcopenic postmenopausal women.

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Correspondence to I J Dionne.

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Aubertin-Leheudre, M., Lord, C., Khalil, A. et al. Six months of isoflavone supplement increases fat-free mass in obese–sarcopenic postmenopausal women: a randomized double-blind controlled trial. Eur J Clin Nutr 61, 1442–1444 (2007). https://doi.org/10.1038/sj.ejcn.1602695

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602695

Keywords

  • menopause
  • sarcopenia
  • muscle mass
  • phytoestrogens
  • appendicular fat-free mass
  • muscle mass index

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