This study aimed at assessing the associations of dietary fat with the risk of age-related maculopathy (ARM), in the framework of a population-based study from southern France. Nutritional data were collected using a dietitian-administered food-frequency questionnaire. ARM was classified from retinal photographs using the international classification and included neovascular age-related macular degeneration, geographic atrophy, soft indistinct drusen, soft distinct drusen associated with pigmentary abnormalities. After multivariate adjustment, high total, saturated and monounsaturated fat intake were associated with increased risk for ARM (odds ratio (OR)=4.74, P=0.007; OR=2.70, P=0.04; and OR= 3.50, P=0.03, respectively). Total polyunsaturated fatty acid was not significantly associated with ARM. Total and white fish intake was not significantly associated with ARM, but fatty fish intake (more than once a month versus less than once a month) was associated with a 60% reduction in risk for ARM (OR=0.42, P=0.01).
This is a preview of subscription content, access via your institution
Open Access articles citing this article.
Human Genetics Open Access 31 July 2019
Subscribe to Journal
Get full journal access for 1 year
only $9.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Get time limited or full article access on ReadCube.
All prices are NET prices.
Baird PN, Guida E, Chu DT, Vu HT, Guymer RH (2004). The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 45, 1311–1315.
Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD et al. (1995). An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol 39, 367–374.
Cho E, Hung S, Willett WC, Spiegelman D, Rimm EB, Seddon JM et al. (2001). Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr 73, 209–218.
Daures JP, Gerber M, Scali J, Astre C, Bonifacj C, Kaaks R (2000). Validation of a food-frequency questionnaire using multiple-day records and biochemical markers: application of the triads method. J Epidemiol Biostat 5, 109–115.
Delcourt C, Diaz JL, Ponton-sanchez A, Papoz L, The Pola Study Group (1998). Smoking and age-related macular degeneration: the POLA study. Arch Ophthalmol 116, 1031–1035.
Delcourt C, Lacroux A, Carriere I, Group PS (2005). The three-year incidence of age-related macular degeneration: the ‘Pathologies Oculaires Liees a l’Age' (POLA) Prospective Study. Am J Ophthalmol 140, 924–926.
Donoso LA, Kim D, Frost A, Callahan A, Hageman G (2006). The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 51, 137–152.
Espinosa-Heidmann DG, Sall J, Hernandez EP, Cousins SW (2004). Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E. Invest Ophthalmol Vis Sci 45, 260–266.
Heuberger RA, Mares Perlman JA, Klein R, Klein BE, Millen AE, Palta M (2001). Relationship of dietary fat to age-related maculopathy in the Third National Health and Nutrition Examination Survey. Arch Ophthalmol 119, 1833–1838.
Klein R, Peto T, Bird A, Vannewkirk MR (2004). The epidemiology of age-related macular degeneration. Am J Ophthalmol 137, 486–495.
Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW et al. (2005). Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci USA 102, 11900–11905.
Mares Perlman JA, Brady WE, Klein R, Vandenlangenberg GM, Klein BE, Palta M (1995). Dietary fat and age-related maculopathy. Arch Ophthalmol 113, 743–748.
Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, Pokharel GP et al. (2004). Global data on visual impairment in the year 2002. Bull World Health Organ 82, 844–851.
SanGiovanni JP, Chew EY (2005). The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res 24, 87–138.
Seddon JM, Cote J, Rosner B (2003). Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake. Arch Ophthalmol 121, 1728–1737.
Seddon JM, Rosner B, Sperduto RD, Yannuzzi L, Haller JA, Blair NP et al. (2001). Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol 119, 1191–1199.
Smith W, Mitchell P, Leeder SR (2000). Dietary fat and fish intake and age-related maculopathy. Arch Ophthalmol 118, 401–404.
Willett W (1998). Nutritional Epidemiology. Oxford University Press: New York.
Zareparsi S, Reddick AC, Branham KE, Moore KB, Jessup L, Thoms S et al. (2004). Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center. Invest Ophthalmol Vis Sci 45, 1306–1310.
This study was supported by the Institut National de la Santé et de la Recherche Médicale, Paris, France; by grants from the Fondation de France, Department of Epidemiology of Ageing, Paris, the Fondation pour la Recherche Médicale, Paris, the Région Languedoc-Roussillon, Montpellier, France and the Association Retina-France, Toulouse; and by financial support from Rhônes Poulenc, Essilor and Specia, and the Centre de Recherche et d'Information Nutritionnelle, Paris.
Guarantor: C Delcourt.
Contributors: CD designed and managed the study and wrote the first draft. IC performed the data management and carried out the statistical analysis. AL managed the data collection. MG provided the nutritional questionnaire and participated in the study design and data analysis. J-PC participated in the study design and data analysis and interpretation. All authors were involved in writing the final draft of the manuscript.
About this article
Cite this article
Delcourt, C., Carrière, I., Cristol, JP. et al. Dietary fat and the risk of age-related maculopathy: the POLANUT Study. Eur J Clin Nutr 61, 1341–1344 (2007). https://doi.org/10.1038/sj.ejcn.1602685
- age-related maculopathy
- dietary fat
- unsaturated fats
This article is cited by
Dietary fatty acid intake, plasma fatty acid levels, and the risk of age-related macular degeneration (AMD): a dose–response meta-analysis of prospective cohort studies
European Journal of Nutrition (2021)
Human Genetics (2019)
European Journal of Epidemiology (2016)